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排序方式: 共有10000条查询结果,搜索用时 78 毫秒
91.
Seulah Lee Yeon Ji Suh Seonguk Yang Dong Geun Hong Akihito Ishigami Hangun Kim Jae-Seoun Hur Seung-Cheol Chang Jaewon Lee 《International journal of molecular sciences》2021,22(4)
Oxidative stress, mitochondrial dysfunction, and neuroinflammation are strongly associated with the pathogenesis of Parkinson’s disease (PD), which suggests that anti-oxidative and anti-inflammatory compounds might provide an alternative treatment for PD. Here, we evaluated the neuroprotective effects of evernic aid (EA), which was screened from a lichen library provided by the Korean Lichen Research Institute at Sunchon National University. EA is a secondary metabolite generated by lichens, including Ramalina, Evernia, and Hypogymnia, and several studies have described its anticancer, antifungal, and antimicrobial effects. However, the neuroprotective effects of EA have not been studied. We found that EA protected primary cultured neurons against 1-methyl-4-phenylpyridium (MPP+)-induced cell death, mitochondrial dysfunction, and oxidative stress, and effectively reduced MPP+-induced astroglial activation by inhibiting the NF-κB pathway. In vivo, EA ameliorated MPTP-induced motor dysfunction, dopaminergic neuronal loss, and neuroinflammation in the nigrostriatal pathway in C57BL/6 mice. Taken together, our findings demonstrate that EA has neuroprotective and anti-inflammatory effects in PD models and suggest that EA is a potential therapeutic candidate for PD. 相似文献
92.
在传统检测手段无法满足越来越趋向大型化、超大型化的塔器整体两侧直线度的过程检测和控制保障背景下,打破传统思维,大胆创新检测手段,自行设计开发出超大型塔器整体两侧直线度检测整套技术,充分解决超大型塔器整体两侧直线度的检测难题. 相似文献
93.
User Modeling and User-Adapted Interaction - Personality plays a pivotal role at work. Many scholars have investigated the association between personality and language usage habits in the English... 相似文献
94.
95.
Ting Yu Wen Nie Zehua Hong Yihong He Jing Chen Xue Mi Shuping Yang Xiaoling Li Bilan Wang Yunzhu Lin Xiang Gao 《Advanced functional materials》2021,31(22):2100715
Normalizing the tumor-induced immune deficiency in the immunosuppressive tumor microenvironment (TME) through increasing the efficient infiltration and activation of antitumoral immunity in TME is the core of promising immunotherapy. Herein, a Cyclo(Arg-Gly-Asp-d -Phe-Lys) (RGD) peptides-modified combinatorial immunotherapy system based on the self-assembly of the nanoparticles named RGD-DMA composed of RGD-PEG-PLA, methoxy poly(ethylene glycol)-poly(lactide) (MPEG-PLA) and 1,2-Dioleoyl-3-trimethylammonium-propane (DOTAP) is used to codeliver the immunostimulatory chemokine CCL19-encoding plasmid DNA (CCL19 pDNA) and immune checkpoint ligand PD-L1 inhibitor (BMS-1). The RGD-DMA/pCCL19-BMS-1 system not only exhibited significant inhibition of tumor progression but also induced locally high concentrations of immunostimulatory cytokines at tumor sites without causing an obviously systemic inflammatory response. The immunosuppressive TME is efficaciously reshaped by the coadministration of RGD-DMA/pCCL19 and BMS-1, as indicated by the activated T lymphocytes, increased intratumoral-infiltration of mature dendritic cells (DCs), and the repolarization of macrophages from pro-tumoral M2-phenotype toward tumoricidal M1-phenotype. The upregulated PD-L1 expression at tumor sites caused by the increased IFN-γ levels after immunostimulatory gene therapy further demonstrated the synergistic effects of BMS-1 in counteracting the inhibitory role of PD-L1 expression in antitumor immunity. Therefore, the combination of immunostimulating therapy and immune checkpoint inhibitor that synergistically target multiple immune regulatory pathways demonstrates significant potential as a novel immunotherapy approach. 相似文献
96.
Qiang Wang Lei Shen Tong Xue Gao Cheng Cheng Zhi Huang Hong Jin Fan Yuan Ping Feng 《Advanced functional materials》2021,31(2):2002187
The {100} facet of single-crystalline TiO2(B) is an ideal platform for inserting Li ions, but it is hard to be obtained due to its high surface energy. Here, the single-crystalline TiO2(B) nanobelts from H2Ti3O7 with nearly 70% {100} facets exposed are synthesized, which significantly enhances Li-storage capacity. The first-principle calculations demonstrate an ab in-plane 2D diffusion through the exposed {100} facets. As a consequence, the nanobelts can significantly accommodate Li ions in LiTiO2 formula with specific capacity up to 335 mAh g−1, which is in good agreement with the electrochemical characterizations. Coating with conductive and protective poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate), the cut-off discharge voltage is as low as 0.5 V, leading to a capacity of 160.7 mAh g−1 after 1500 cycles with a retention rate of 66% at 1C. This work provides a practical strategy to increase the Li-ion capacity and cycle stability by tailoring the crystal orientation and nanostructures. 相似文献
97.
98.
Cheng-Che Tsai Wu-Han Liao Sheng-Yuan Chu Cheng-Shong Hong Mei-Chieh Yu Yun-You Lin Zhi-Yuan Wei 《Journal of the European Ceramic Society》2021,41(4):2472-2481
Multilayer piezoelectric ceramics must be sintered in a reducing atmosphere, preventing oxidation of the inner base metal. Plate-like textured (Ba, Ca)(Ti, Sn, Hf)O3 ceramics with a <001> preferred orientation were successfully developed at a low oxygen partial pressure (PO2:10?8 atm) using a BaTiO3 (BT) template with sintering temperatures < 1300 °C, which is beneficial for multilayer applications using base metal co-firing with ceramics. When adding the 3 wt% BT template, the proposed samples had a Lottgering factor of 84 %, piezoelectric coefficients d33 = 324 pC/N, -d31 = 122 (pC/N), and Qm = 452, and the strain values increased from 0.07 % for the randomly oriented ceramics to 0.115 % at 20 kV/cm for the textured ceramics, confirming that the texturing behavior assisted the grain growth and improved both the soft and hard behaviors and insulation resistance of the proposed lead-free ceramics. These findings make a significant contribution to the production of high-power piezoelectric components. 相似文献
99.
100.
Multidimensional Systems and Signal Processing - Although sparse spectrum fitting algorithm has good multi-target resolution, the performance is decreased under the influence of strong... 相似文献